Differential Cataractogenic Potency of TGF-/3X, -j82, and -/33 and Their Expression in the Postnatal Rat Eye
نویسنده
چکیده
METHODS. Lens epithelial explants and whole lenses from weanling rats were cultured with TGF-/3,, TGF-j32, or TGF-j33 at concentrations ranging from 0.025 ng/ml to 4 ng/ml for 3 to 5 days. Cataractous changes were monitored daily by phase contrast microscopy and by immunofluorescent detection of cataract markers a-smooth muscle actin and type I collagen. Expression of TGF-/3 was studied by immunofluorescence and in situ hybridization on eye sections from neonatal and weanling rats.
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تاریخ انتشار 2005